sa RNA Vaccine

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• self-amplifying mRNA vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety.
• The key to realizing the full potential of these vaccines is efficient delivery of nucleic acid to the cytoplasm of a cell, where it can amplify and express the encoded antigenic protein.
• Self-amplifying RNA (saRNA) is a type of mRNA that also encodes viral replicase, which enables the RNA to self-replicate upon delivery into the cell.

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